Participants from science, associations and practice were happy to meet again in person and exchange different views on the important topic of antibiotic resistances in livestock farming. The second day of the Kaesler Forum started with an insight into the housing management and the use of antibiotics. Prof. Jens Peter Nielsen introduced insights into the Danish swine production over the last 20 years and the different learnings from their strict regulations regarding the usage of antibiotics. The importance of welfare, management and the right handling of the animals to keep them healthy was underlined by Prof. Nicole Kemper from the Veterinary University of Hanover. Prof. Jeroen Dewulf explained the role of biosecurity and a good hygiene management on the farms to reduce the use of antibiotics. An outlook for the future was given by Dr. Pieter Knap (Genus PIC) and Dr. Simon Lillico (The Roslin Institute, University of Edinburgh) regarding the future role of breeding and the effect of genomic editors to have more disease resilient animals. The future possibilities of precision livestock feeding was shown by Dr. Tomas Norton from KU Leuven. The Kaesler Forum 2022 was closed by the speech of Dr. Eva-Maria Saliu who explained the role of feed ingredients on animal health and that it seems trivial but there is still much to achieve with the right choice of ingredients.