Antioxidants and L-carnitine – a clever combination to combat oxidative stress
High performing animals are continuously exposed to stress of different origins, which results in oxidative stress. Oxidative stress is defined as an excess of free radicals and / or insufficient protection through antioxidants. Under ideal conditions a sensitive balance prevails between the quantity of free radicals and the body´s own radical defense system.
However, even minor changes can disturb this balance: Increased formation of free radicals during increased energy metabolism or through immune response as well as pro-oxidizing inorganic compounds and mycotoxins are factors for oxidative stress.
Oxidative stress plays an important role in many degenerative diseases. The activation of proinflammatory genes and production of cytokines lead to inflammation with differing seriousness.
An important factor which is directly linked to feeding is the intake of poor quality feed containing high amounts of oxidized fatty acids and free radicals. Metabolic stress due to high performance is another important factor. It occurs inter alia during the periparturient period and high lactation in dairy cows and sows.
Metabolic stress is characterized by increased body fat mobilization, increased non-esterified fatty acids (NEFA), and the formation of ketone bodies.
L-carnitine and antioxidants prevent oxidative stress at different levels. Dietary antioxidants prevent feed-induced oxidative stress and L-carnitine supports the animals’ metabolism to strengthen the endogenous radical defense system. The combination of both products uses their synergistic effects to combat oxidative stress most effectively. (Download article)